ITAM Multiplicity and Thymocyte Selection
نویسندگان
چکیده
منابع مشابه
Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection
The immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains associated with the T cell receptor (TCR) are crucial for TCR signaling. To probe the role of the CD3gamma-ITAM in T cell development, we created knock-in mice in which the CD3gamma chain of the TCR complex is replaced by a mutant signaling-deficient CD3gamma chain, lacking the CD3gamma-ITAM. This mutation results in ...
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The T-cell antigen receptor (TCR) complex contains 10 copies of a di-tyrosine Immunoreceptor-Tyrosine-based-Activation-Motif (ITAM) that initiates TCR signalling by recruiting protein tyrosine kinases. ITAM multiplicity amplifies TCR signals, but the importance of this capability for T-cell responses remains undefined. Most TCR ITAMs (6 of 10) are contributed by the CD3ζ subunits. We generated ...
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ژورنال
عنوان ژورنال: Immunity
سال: 2000
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80210-1